Study Shows Pine Bark Naturally Reduces Osteoarthritis Knee Pain
A study published last month demonstrates the natural pain reduction properties of pine bark extract for COX inhibition. Patients who supplemented with pine tree bark extract known as PycnogenolŽ (pic-noj-en-all) demonstrated a decrease in pain and inflammation by lowering cyclooxygenase activity, also known as COX-1 and COX-2. The study was published in the January issue of Biomedicine & Pharmacotherapy.
The clinical study conducted at the University of Würzburg in Germany investigated the inhibitory effects of Pycnogenol involved in the development of pain associated with arthritis. Two groups of patients were supplemented with Pycnogenol after an initial basal blood sample. The first group consisting of five patients supplemented with 200 mg of Pycnogenol for five days where another blood sample was taken. The patients' blood samples revealed direct inhibitory effect on cyclooxygenase activity. Inhibition of COX-1 was apparent in three of five study participants. A second group of 10 patients supplemented with a one-time dose of 300 mg Pycnogenol to determine how quickly the effect was measurable. Only 30 minutes after ingestion of Pycnogenol, blood samples indicated a statistically significant increase in the inhibitory effects of both COX-1 and COX-2.
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